Not unless it's a boss with incredibly low armor and enough HP to not die in one hit, such as bosses in FH/DF/BF:
Meathead
HP: 2300
DEF: 7
Silknight the Sorceress
HP: 2300
DEF: 7
Brom Dandy
HP: 2300
DEF: 8
Skeller Krunch
HP: 2300
DEF: 8
Babrax the Demon
HP: 2300
DEF: 8
Of course to get the maximum amount of damage possible, one would have to debuff using all character classes and the boss would have to survive that as well.
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