As much as I thought SL would be awesome on the PC, it's not... yet. The game is still geared too much toward multi-touching.

We need a hotkey to enter the menu.
We need hotkeys to use potions.
We need a hotkey to show the minimap. (Tab?)
Selling items is difficult and painful. It takes way too many clicks.
Many screens don't have a default binding for enter/spacebar buttons. (You can't revive yourself, for example, by hitting the spacebar.)
It would be nice to be able to navigate menus via arrow keys.

Also, the autotargetting (right/left arrows) can target enemies waaaaay far off.