When you enter the Old Town Hospital, you first have to kill enough ordinary ennemies.
If there are other players, this may already be done.
Once enough ordinary ennemies have been killed, minibosses appear alternatively in one of the 3 rooms at the top of the area :
These minibosses have several names :
You first have to kill the minibosses located in the left and right rooms, then a miniboss appears in the third room at the top center.
When you have killed this miniboss, the keyphrase appears : "Search for Patient Zero ..."
At these point, Patient Zero has a chance to appear.
But after 1 minute or 2, there is a message saying that a doctor is back :
So you have to fight a new miniboss appearing in the third room :
After having defeated him, the keyphrase appears again : "Search for Patient Zero ..."
And for 1 or 2 minutes, you have another chance to find Patient Zero, just walking around.
When a message appears that a doctor in back, just fight him to have another chance. The left and right rooms have no more importance, only the third room located in the center is important : in this room new minibosses appear every few minutes, and when you kill them, the keyphrase appears "Search for Patient Zero ..." .
So you have to alternatively walk around and kill the miniboss who unlocks the keyphrase.
Whith this method, you'll find Patient Zero in less than 1 hour :
He is much weaker now than he used to be at the beginning. He's approximately as strong as other minibosses.
If you meet him, call other players in the area so they have a chance to get a nice drop.
He usually drops 10 or 15 energy bonus, and there is probably a chance to get other rare items.
When you beat him, you'll get the Patient Zero achievement :
Note that the first time the keyphrase "Search for Patient Zero ..." appears, this also unlocks a secret weapons shop, located at the center of the area :
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