Due to it being highly contingent on the other classes skill usage, what would people suggest a good skill cycle would be?

I stick to one cycle usually, which is root/break/scream/blast, or just scream/blast to get a combo in before I get killed. With one set of 55-56s I maybe got one or two megas, mainly out of luck. With another, I specifically remember 6 megas against the Sewer Queen, and a few against King too.

So, what does everyone think?