Zeus is correct here....generally, charged Nox is the way to go. The only consideration on whether to charge or not is based upon how tightly grouped mobs are. If your Nox can affect the maximum number of targets, then charge it, otherwise, uncharged will suffice.
Nox hits for approximately 150-175 DMG per second spread over 6 mobs - that's 900-1050 DMG per second total. Aimed, may hit for 1.5 - 1.8k (perhaps more based upon your DMG) when critting.
So, in the 2 seconds it takes for Aimed to cool off, you can achieve the same or even more overall DMG. Better yet, Nox stacks, so a party of rogues can keep feeding Nox yielding a total of 2700 - 3150 DMG per second (assume at least one tank or Sorc). So, if you charge Nox, use Aimed and either Pierce or Traps, your overall damage output is substantially higher.
Another point of consideration is that Nox is consistent damage, regardless of target armor. Nox, unlike every other skill, also can deal damage to shielded bosses like Bael in Rooks Nest or Overgrowth when he closes up. A combination of George stunning Overgrowth just prior to him closing and subsequently launching Nox means an easy elite boss kill.
Best part of Nox is that you can use it as your killing blow; that way, you aren't wasting time, or mana, killing mobs when they get to 2-3% HP. Instead, you can focus your attention on other mobs that have higher health and not burn mana with an Aimed Shot on a mob that has maybe 300 HP left.
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