The mez thing is because it auto-changes everyone's target. If you get swarmed by lesser enemies, feel free. The problem is when you are fighting, for instance, a Vular in Numa. Then everone's target auto-changes to one of the enemies in the next group, soon you are fighting 2 Vular at the same time. Some groups can handle it, some cannot.
If your engineer uses pain on the toughest enemy, it will stun them long enough to kill most of the adds. Most commandos and engineers at 25 and above can tank a vular for a few seconds without dying anyway, even longer if someone spams heals.
I guess the point is: DO NOT just spam skills. Know what each one does and when to use it. Using the wrong skill at the wrong time will not make you very many friends.
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