Thread like these make me mad because they are full of misconception and disinformation.
Time for a pro to tell you the truth about chests. Read carefully because I will not repeat myself.
Opening all chests in an instance before defeating the boss does increase your chances of a rare drop by 0.5%. This has been proven by doing 1000 runs and comparing 500 with chests vs no chests.
Not opening a single chest will not increase your chances at all.
But to be truthful this small advantage does not compare to the real trick to getting pinks, at least once per hour, by making sure your inventory is empty when you get to the boss and that you have no pinks equipped. The game has a fail safe to keep players interested and if it sees that you do not have good gear it will increase your chances for a good drop. Well known in specialized farmer circles.
Now the secret is out!
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